Birmingham Metabolomics Training Centre: Course List (March-April 2018)

12 February 2018

Birmingham Metabolomics Training Centre: Course List (March-April 2018)

21-23 March 2018
Introduction to Metabolomics for the Microbiologist
Venue: Birmingham Metabolomics Training Centre, School of Biosciences, University of Birmingham, Birmingham, UK.

Limited bursaries are now available for PhD students funded by NERC, which make the registration for this course FREE to these students.

This three-day course will introduce the attendees in how untargeted metabolomics can be applied to study microbial systems in academic and industrial research. The course will provide an overview of the metabolomics pipeline from experimental design to sample preparation and data acquisition to data analysis/interpretation. The course will be led by experts in the field of metabolomics and will include lectures, hands-on laboratory sessions in sample preparation and data acquisition and computer workshops focused on data processing and data analysis.

Topics covered:
• Introduction to metabolomics, both targeted and untargeted approaches
• Experimental design and the importance of quality control samples in untargeted metabolomics
• Analytical strategies applied in metabolomics with a focus on mass spectrometry
• Hands-on laboratory sessions focused on sample preparation and to include metabolic quenching and extraction procedures, intracellular and exometabolome samples and polar and non-polar extraction methods
• Hands-on laboratory sessions focused on sample analysis for untargeted metabolomics studies using an Acquity UPLC coupled to a Xevo QToF mass spectrometer
• Hands-on workshop focused on data processing and data analysis
• Hands-on workshop focused on an introduction to metabolite identification
• Question and answer session with the experts
Level: The course is aimed at individuals with minimal experience of applying metabolomics in their research and no or limited experience of using a liquid chromatography – mass spectrometer. The attendees will leave the course understanding and being able to apply the metabolomics pipeline in their research.

For more information and to register, please click here


2-27 April 2018
Metabolomics Data Processing and Data Analysis
Venue: Online

This online course will explore the tools and approaches that are used to process and analyse metabolomics data, we will investigate the challenges that are typically encountered in the analysis of metabolomics data and provide solutions to overcome these problems. The course will be delivered using a combination of short videos, articles, discussions, and online workshops with step-by-step instructions and test data sets. We will provide quizzes, polls and peer review exercises each week, so that you can review your learning throughout the course.

Course Syllabus:
• An introduction to metabolomics
• An overview of the untargeted metabolomics workflow
• The influence of experimental design and data acquisition on data analysis and data quality
• Processing of NMR data
• Processing direct infusion mass spectrometry data
• Processing liquid chromatography-mass spectrometry data
• Reporting standards and data repositories
• Data analysis, detecting outliers and drift, and pre-treatment methods
• Univariate data analysis
• Multivariate data analysis (including unsupervised and supervised approaches)
• The importance of statistical validation of results
• Computational approaches for metabolite identification and translation of results into biological knowledge
• What are the future challenges for data processing and analysis in metabolomics

Level: The course would be ideally suited to MSc / PhD students or scientists who are in the early stages of analysing metabolomics data. No previous knowledge of the data processing and statistical analysis approaches is assumed, but a basic understanding of the metabolome, and the analytical techniques applied in the metabolomics field would be beneficial. A pre-course recommended reading list will be provided.

For further information and to register, please click here


16-17 April 2018
Metabolite identification with the Q Exactive and LTQ Orbitrap
Venue: Birmingham Metabolomics Training Centre, School of Biosciences, University of Birmingham, Birmingham, UK.

Limited bursaries are now available for PhD students funded by NERC, which make the registration for this course FREE to these students.

This 2-day course will provide a hands-on approach to teach the latest techniques and tools available to perform metabolite identification. We will apply these tools on the Q Exactive and LTQ Orbitrap mass spectrometry family. The course is targeted towards students and researchers who are actively applying metabolomics.

The course will be led by experts in the field and include significant hands-on experience using both the Q Exactive and LTQ Orbitrap instruments to perform:
• Data dependent acquisition
• Data independent acquisition
• MS/MS and MSn data acquisition.
The course will finish with a session on the tips and tricks from the experts and an opportunity to ask questions.

For further information and registration details, please click here


 

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